Genetics Doubts

explain y Io(gene for blood group o) is recessive to both iA and iB(ie alleles for blood group A and B respectively)..
2.Describe how a single base deletion in the allele Io leads to the synthesis of an inactive protein?


 O is always the recessive. It would barely shows unless it is recessive. As for a single base deletion, point mutation I'll call it. Base deletion will produce frame shift in a code. It might delete the gene coding for the shape of the active site or so, altering the tertiary structure of the protein. The substrate cannot bind to the active site and thus leading to an inactive protein. You look under cystic fibrosis. It's mostly cause by base deletion.